Age-dependent effects of diabetes and obesity on liver-related events in non-alcoholic fatty liver disease: Subanalysis of CLIONE in Asia.
Yuya SekoMiwa KawanakaHideki FujiiMichihiro IwakiHideki HayashiHidenori ToyodaSatoshi OedaHideyuki HyogoAkihiro MorishitaKensuke MunekageKazuhito KawataSakura YamamuraKoji SawadaTatsuji MaeshiroHiroshi TobitaYuichi YoshidaMasafumi NaitoAsuka ArakiShingo ArakakiTakumi KawaguchiHidenao NoritakeMasafumi OnoTsutomu MasakiSatoshi YasudaEiichi TomitaMasato YonedaAkihiro TokushigeYoshihiro KamadaHirokazu TakahashiShinichiro UedaShinichi AishimaYoshio SumidaTakeshi OkanoueYoshito ItohHirokazu Takahashinull nullPublished in: Journal of gastroenterology and hepatology (2022)
Type 2 diabetes mellitus and obesity contributed to LRE in younger and older patients, respectively, along with advanced fibrosis. Therefore, controlling T2DM in patients younger than 65 years and controlling weight in patients 65 years and older could prevent LRE. The development of age-dependent screening and management strategies is necessary for patients with NAFLD.