Mitochondrial reactive oxygen species scavenging attenuates thrombus formation in a murine model of sickle cell disease.

Gowtham K Annarapu Deirdre Nolfi-Donegan Michael ReynoldsYinna WangSruti Shiva

Published in: Journal of thrombosis and haemostasis : JTH (2021)

These data demonstrate that mtROS significantly contribute to the mechanism of hemolysis-induced thrombosis in vivo and suggest a potential role for mitochondrially targeted antioxidant therapy in hemolysis and SCD-related thrombosis.

Keyphrases

sickle cell disease
reactive oxygen species
pulmonary embolism
oxidative stress
diabetic rats
red blood cell
high glucose
electronic health record
drug induced
cancer therapy
anti inflammatory
stem cells
endothelial cells
machine learning
drug delivery
cell therapy
stress induced