LEDT and Idebenone treatment modulate autophagy and improve regenerative capacity in the dystrophic muscle through an AMPK-pathway.

Heloina Nathalliê Mariano da SilvaEvelyn Mendes FernandesValéria Andrade PereiraDaniela Sayuri MizobutiCaroline CovattiGuilherme Luiz da RochaElaine Minatel

Published in: PloS one (2024)

These results suggest that LEDT and IDE treatments enhance autophagy and prevented muscle degeneration in the dystrophic muscle of the experimental model. These findings illustrate the potential efficacy of LEDT and IDE treatment as an alternative therapy focused on muscle recovery in the dystrophic patient.

Keyphrases

skeletal muscle
stem cells
cell death
oxidative stress
mesenchymal stem cells
signaling pathway
combination therapy
climate change
smoking cessation
human health