Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages.

Paballo NkoneShayne LoubserThomas C QuinnAndrew D ReddArshad IsmailCaroline T TiemessenSimnikiwe H Mayaphi

Published in: Virology journal (2022)

Deep sequencing revealed many Pol CTL epitopes, including some not previously reported for HIV-1 subtype C. The findings of this study support the inclusion of RT and IN epitopes in HIV-1 vaccine candidates as these proteins harbour many CTL epitopes.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
single cell
south africa
genome wide
gene expression
peripheral blood