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Enzyme-Responsive Molecular Assemblies Based on Host-Guest Chemistry.

Xiao XiaoZhirui XuWenkai WangSiyuan SunYan QiaoLingxiang JiangYun YanJianbin Huang
Published in: Langmuir : the ACS journal of surfaces and colloids (2021)
Recent years have witnessed a growing interest in the design of enzyme-responsive molecular assemblies that hold appealing applications in the fields of disease-related sensing, imaging, and drug delivery. Cyclodextrins (CDs) are amylase-cleavable host molecules that can associate with surfactants, alkanes, alkyl amines, fatty alcohols, and aromatic compounds to form diverse supramolecular structures. In this work, we report a versatile supramolecular platform to construct enzyme-responsive nanosystems via host-guest interactions, in which complexation between CDs and surfactants eventually leads to the formation of a variety of nanostructures such as vesicles and microtubes. These supramolecular structures are capable of loading water-soluble molecules or functional nanoparticles, which can be actively released on-demand in the presence of α-amylase. This universal strategy to fabricate enzyme-responsive supramolecular systems was further demonstrated with a range of surfactants with anionic, cationic, and nonionic headgroups. Our results highlight a versatile platform for the exploration of biologically responsive self-assembly with potential applications as controlled-release systems and microrobots.
Keyphrases
  • water soluble
  • cancer therapy
  • drug delivery
  • high resolution
  • quantum dots
  • high throughput
  • energy transfer
  • ionic liquid
  • single molecule
  • climate change
  • mass spectrometry
  • single cell
  • amino acid