Porphyromonas gingivalis LPS-stimulated BMSC-derived exosome promotes osteoclastogenesis via miR-151-3p/PAFAH1B1.

Jia-Chen DongYue LiaoWei ZhouMeng-Jun SunHuan-Yu ZhangYan LiZhong-Chen Song

Published in: Oral diseases (2024)

Porphyromonas gingivalis-LPS could regulated bone metabolism by inhibiting proliferation and osteogenesis of BMSCs directly. Also, P. gingivalis-LPS-stimulated BMSCs-EXO promoted osteoclastogenesis via activating miR-151-3p/PAFAH1B1 signal pathway.

Keyphrases

inflammatory response
signaling pathway
anti inflammatory
lps induced
bone loss
bone regeneration
bone mineral density
transcription factor
soft tissue