Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice.

Alexander A PieperAlexander L RakhmilevichDaniel V SpiegelmanRavi B PatelJen BirstlerWon Jong JinPeter M CarlsonDeborah H CharychJacquelyn A HankAmy K ErbeWillem W OverwijkZachary S MorrisPaul M Sondel

Published in: Journal for immunotherapy of cancer (2022)

The combination of local RT, BEMPEG, and ICB cured mice with advanced, immunologically cold tumors and distant metastasis in a T cell-dependent manner, suggesting this triple combination warrants clinical testing.

Keyphrases

radiation therapy
high fat diet induced
cell cycle
adipose tissue
locally advanced