The Effects of Taurocholic Acid on Biliary Damage and Liver Fibrosis Are Mediated by Calcitonin-Gene-Related Peptide Signaling.

Romina MancinelliLudovica CeciLindsey KennedyHeather FrancisVik MeadowsLixian ChenCarpino GuidoKonstantina KyritsiNan WuTianhao Zhou Keisaku SatoLuigi PannaraleShannon GlaserSanjukta Chakraborty Gianfranco AlpiniEugenio GaudioPaolo OnoriAntonio Franchitto

Published in: Cells (2022)

Modulation of the TC/ α-CGRP/CALCRL/PKA/ERK1/2/TGF-β1/VEGF axis may be important in the management of cholangiopathies characterized by BA accumulation.

Keyphrases

liver fibrosis
signaling pathway
vascular endothelial growth factor
transforming growth factor
oxidative stress
endothelial cells
cell proliferation
copy number
genome wide
pi k akt
genome wide identification
gene expression
epithelial mesenchymal transition