The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading.

Roberta TaralloGiorgio GiuratoGiuseppina BrunoMaria RavoFrancesca RizzoAnnamaria SalvatiLuca RicciardiGiovanna MarcheseAngela CordellaTeresa RoccoValerio GigantinoBiancamaria PierriGiovanni CimminoLuciano MilanesiConcetta AmbrosinoTuula A NymanGiovanni NassaAlessandro Weisz

Published in: Genome biology (2017)

These results demonstrate that AGO2 can act as a pleiotropic functional partner of ERβ, indicating that both factors are endowed with multiple roles in the control of key cellular functions.

Keyphrases

endoplasmic reticulum
estrogen receptor
breast cancer cells
copy number
genome wide
transcription factor
binding protein
hepatitis c virus
hiv infected
genome wide analysis