Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival.
Donald M MockSean R StowellRobert S FrancoSvetlana V KyossevaDemet NalbantRobert L SchmidtGretchen A CressRonald G StraussJosé A CancelasMelissa von GoetzAnne K NorthJohn A WidnessPublished in: Transfusion (2022)
We conclude re-exposure of immunized subjects to BioRBC can induce anamnestic antibody response that can cause an underestimation of RCS. To minimize chances of antibody induction and underestimation of RCS, we recommend an initial BioRBC exposure volume of ≤10 mL and label densities of ≤18 μg/mL.