Plasma neurofilament light levels associate with muscle mass and strength in middle-aged and older adults: findings from GenoFit.
Jedd PrattGiuseppe De VitoRicardo SeguradoLudmilla PessanhaJackie DolanMarco Vincenzo NariciColin BorehamPublished in: Journal of cachexia, sarcopenia and muscle (2022)
Our study clearly demonstrates the indicative pertinence of circulating NfL levels to sarcopenic domains, supporting its potential use as a biomarker of sarcopenia. More studies are needed, however, to further illuminate the diagnostic value of circulating NfL. Future research should explore whether NfL levels are more powerfully linked with muscle strength than mass and whether sex mediates the relevance of NfL concentrations to sarcopenic phenotypes.