Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study.
Galen Royce-NagelMary JarzebowskiPattrapun WongsripuemtetVijay KrishnamoorthyMatthew FullerTetsu OhnumaMiriam TreggiariMiguel YaportJulien CobertEthan GarriganRaquel BartzKarthik RaghunathanPublished in: Critical care explorations (2024)
In a diverse sample of U.S. hospitals, about one in 30 patients mechanically ventilated with COVID-19 received ketamine infusions. Early ketamine may have an association with higher hospital mortality, increased total cost, ICU stay, and ventilator days, but no associations for hospital LOS, vasopressor days, and RRT. However, confounding by the severity of illness might occur due to higher extracorporeal membrane oxygenation and RRT use in the ketamine group. Further randomized trials are needed to better understand the role of ketamine infusions in the management of critically ill patients.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- pain management
- intensive care unit
- healthcare
- end stage renal disease
- coronavirus disease
- sars cov
- newly diagnosed
- prognostic factors
- adverse drug
- emergency department
- peritoneal dialysis
- risk factors
- cardiovascular disease
- type diabetes
- chronic pain
- coronary artery disease
- patient reported