Complement blockade with eculizumab for treatment of severe Coronavirus Disease 2019 in pregnancy: A case series.

Richard M Burwick Gabriela DellapianaRachel A NewmanSarah D SmithsonMariam NaqviJohn WilliamsMelissa S WongMartha BautistaAnna GadenShamsah D KazaniDerek A DunnMark H MaSanjay MitterJonathan P R MonteleoneStephan R OrtizSara GhandehariNoah MerinMark I ZakowskiS Ananth Karumanchi

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2022)

We describe use of eculizumab to treat severe COVID-19 in a small series of pregnant and postpartum adults. A larger, controlled study in pregnancy is indicated.

Keyphrases

coronavirus disease
preterm birth
early onset
pregnancy outcomes
sars cov
respiratory syndrome coronavirus
pregnant women
combination therapy
smoking cessation