Non-invasive quantification of acute macrophagic lung inflammation with [ 11 C](R)-PK11195 using a three-tissue compartment kinetic model in experimental acute respiratory distress syndrome.

Laurent BitkerFrançois DhelftSophie LancelotDidier Le BarsNicolas CostesNazim BenzerdjebMaciej OrkiszJean-Christophe Richard

Published in: European journal of nuclear medicine and molecular imaging (2022)

C](R)-PK11195 lung uptake was significantly improved in most lung regions using the 3TCM. This new methodology offers the opportunity to non-invasively evaluate innovative ventilatory strategies aiming at controlling acute lung inflammation.

Keyphrases

acute respiratory distress syndrome
liver failure
oxidative stress
extracorporeal membrane oxygenation
respiratory failure
aortic dissection