Role of Anti-Carbamylated Protein Antibodies Compared to Anti-Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First-Degree Relatives, and Healthy Controls.
H KoppejanL A TrouwJ SokoloveL J LaheyT J W HuizingaI A SmolikD B RobinsonHani S El-GabalawyR E M ToesC A HitchonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2017)
Anti-CarP antibodies are prevalent in FN patients with RA and also more common in their at-risk FDRs compared to healthy controls. The results indicate an association of RF, ACPAs, and anti-CarP with RA that is strongest when all 3 autoantibodies are present. These findings may provide new insights into the evolution of autoimmunity in preclinical RA.