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The variational multiscale formulation for the fully-implicit log-morphology equation as a tensor-based blood damage model.

Stefan HaßlerLutz PauliMarek Behr
Published in: International journal for numerical methods in biomedical engineering (2019)
We derive a variational multiscale (VMS) finite element formulation for a viscoelastic, tensor-based blood damage model. The tensor equation is numerically stabilized by a logarithmic shape tensor description that prevents unphysical, negative eigenvalues. The resulting VMS stabilization terms for this so-called log-morph equation are presented together with their special numerical treatment. Results for a 2D rotating stirrer test case obtained from log-morph simulations with both SUPG and VMS stabilization show significantly improved numerical behavior if compared with Galerkin/least squares (GLS) stabilized untransformed morphology simulation results. The newly proposed method is also successfully applied to a state-of-the-art centrifugal ventricular assist device (VAD), and clear advantages of the VMS stabilization compared with the SUPG-stabilized formulation are presented.
Keyphrases
  • drug delivery
  • finite element
  • oxidative stress
  • heart failure
  • left ventricular
  • molecular dynamics
  • combination therapy
  • high resolution