Near-infrared ratiometric self-assembled theranostic nanoprobe: imaging and tracking cancer chemotherapy.
Xinwei TianZhao LiNing DingJiahang ZhangPublished in: Chemical communications (Cambridge, England) (2020)
We have developed a novel near-infrared ratiometric fluorescent theranostic nanoprobe. Upon reaction with glutathione, it releases a near-infrared fluorophore and chemotherapy drug. Notably, this nanoprobe can selectively kill HeLa and HepG-2 cancer cells over normal HUVEC cells with negligible side effects. Furthermore, this nanoprobe has been successfully applied to real-time fluorescence tracking and imaging cancer therapy in mice.
Keyphrases
- living cells
- fluorescent probe
- single molecule
- cancer therapy
- high resolution
- fluorescence imaging
- cell cycle arrest
- photodynamic therapy
- induced apoptosis
- locally advanced
- quantum dots
- drug delivery
- papillary thyroid
- cell death
- squamous cell carcinoma
- nitric oxide
- mass spectrometry
- radiation therapy
- squamous cell
- cell proliferation
- high fat diet induced
- signaling pathway
- hydrogen peroxide
- chemotherapy induced
- drug induced
- pi k akt
- wild type
- electron transfer