Priming mesenchymal stem cells with α-synuclein enhances neuroprotective properties through induction of autophagy in Parkinsonian models.

Jin Young ShinDong-Yeol KimJieun LeeYu Jin ShinYi Seul KimPhil Hyu Lee

Published in: Stem cell research & therapy (2022)

The present data suggest that MSC priming with α-syn exerts neuroprotective effects through augmented stemness and possibly the enhancement of autophagy-mediated α-syn modulation in Parkinsonian models.

Keyphrases

mesenchymal stem cells
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
stem cells
umbilical cord
electronic health record
bone marrow
blood brain barrier
brain injury
subarachnoid hemorrhage