Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.
Niki L DimouAndre E KimOrlagh FlanaganNeil MurphyVirginia Diez-ObreroAnna ShcherbinaElom Kouassivi AglagoEmmanouil C BourasPeter T CampbellGraham CaseySteven GallingerStephen B GruberMark A JenkinsYi LinVictor MorenoEdward A Ruiz-NarvaezMariana C SternYu TianKostas K TsilidisVolker ArndtElizabeth L BarryJames W BaurleySonja I BerndtStéphane BézieauStephanie A BienD Timothy BishopHermann BrennerArif BudiartoRobert Carreras-TorresTjeng Wawan CenggoroAndrew T ChanJenny Chang-ClaudeStephen J ChanockXuechen ChenDavid V ContiChristopher H DampierMatthew DevallDavid A DrewJane C FigueiredoGraham G GilesAndrea GsurTabitha A HarrisonAkihisa HidakaMichael HoffmeisterJeroen R HuygheKristina JordahlEric KawaguchiTemitope O KekuSusanna C LarssonLoic Le MarchandJuan Pablo LewingerLi LiBharuno MahesworoJohn MorrisonPolly A NewcombChristina C NewtonMireia Obon-SantacanaJennifer OseRish K PaiJulie R PalmerNikos PapadimitriouBens PardameanAnita R PeoplesPaul D P PharoahElizabeth A PlatzJohn D PotterGad RennertPeter C ScacheriRobert E SchoenYu-Ru SuCatherine M TangenStephen N ThibodeauDuncan C ThomasCornelia M UlrichCaroline Y UmFranzel J B van DuijnhovenKala VisvanathanPavel VodickaLudmila VodickovaEmily WhiteAlicja WolkMichael O WoodsConghui QuAnshul KundajeLi HsuW James GaudermanMarc J GunterUlrike PetersPublished in: British journal of cancer (2023)
These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.