Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats.

Xiao MaJian-Xia WenSi-Jia GaoXuan HePeng-Yan LiYu-Xue YangShi-Zhang WeiYan-Ling ZhaoXiao-He Xiao

Published in: The Journal of pharmacy and pharmacology (2018)

The results indicated that PLP could ameliorate ANIT-induced cholestasis in rats and the anti-inflammatory effect of PLP might be related to regulating NF-κB-NLRP3 inflammasome pathway. This study will provide scientific evidence for PLP as a potential drug candidate for cholestasis.

Keyphrases

nlrp inflammasome
drug induced
signaling pathway
anti inflammatory
lps induced
oxidative stress
nuclear factor
pi k akt
diabetic rats
adverse drug
high glucose
emergency department
human health
risk assessment
climate change
toll like receptor