Deletion of Mocos Induces Xanthinuria with Obstructive Nephropathy and Major Metabolic Disorders in Mice.

Delphine SeddaClaire MackowiakJulie PaillouxElodie CulerierAna DudasPauline RontaniNicolas ErardAntoine LefevreSylvie Mavel Patrick Emond Frederic Foucher Marc Le Bert Valerie F J QuesniauxMichael J MihatschBernhard RyffelMadeleine Erard-Garcia

Published in: Kidney360 (2021)

-deficient mice develop a lethal obstructive nephropathy associated with profound metabolic changes. Studying MOCOS functions may provide important clues about the underlying pathogenesis of xanthinuria and other diseases requiring early diagnosis.

Keyphrases

intellectual disability
high fat diet induced
type diabetes
autism spectrum disorder
wild type