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Synthesis of novel azasugar-containing 2'β-C-Me 9-deaza nucleosides as potential anti-hepatitis C virus agents.

Pravin L KotianMinwan WuAjit GhoshKevin J PolachYahya El-KattanV Satish KumarTsu-Hsing LinXiaogang ChengShanta BantiaKrishnan RamanPooran ChandYarlagadda S Babu
Published in: Nucleosides, nucleotides & nucleic acids (2022)
As a part of our ongoing discovery efforts exploring azasugar as agents for treating various unmet medical needs, we prepared analogs of azasugar as potential anti-hepatitis C virus (HCV) agents. Herein we describe the synthesis of novel 2'β-C-Me 9-deazanucleoside azasugar analogs.
Keyphrases
  • hepatitis c virus
  • human immunodeficiency virus
  • molecular docking
  • healthcare
  • small molecule
  • human health
  • climate change
  • hiv infected