Single-Cell Integration Analysis of Heterotopic Ossification and Fibrocartilage Developmental Lineage: Endoplasmic Reticulum Stress Effector Xbp1 Transcriptionally Regulates the Notch Signaling Pathway to Mediate Fibrocartilage Differentiation.

Yisheng ChenYaying SunYuzhen Xu Wei-Wei LinZhiwen LuoZhihua HanShaohua LiuBeijie QiChenyu SunKen GoX-R KangJiwu Chen

Published in: Oxidative medicine and cellular longevity (2021)

A systematic analysis of the differentiation landscape and cellular homogeneity facilitated a molecular understanding of the phenotypic similarities between cells in the fibrocartilaginous region of tendon and HO cells. Furthermore, by identifying Xbp1 as a hub regulator and by conducting a ligand-receptor analysis, we propose a potential Xbp1/Jag1/Notch signaling pathway.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
signaling pathway
single cell
pi k akt
oxidative stress
cell cycle arrest
cell proliferation
epithelial mesenchymal transition
rna seq
risk assessment
regulatory t cells
high throughput
single molecule
immune response
cell death