Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma.
Mary M PrunickiLaurel StellDeendayal DinakarpandianMariangels de Planell-SaguerRichard W LucasS Katharine HammondJohn R BalmesXiaoying ZhouTara PaglinoChiara SabattiRachel L MillerKari C NadeauPublished in: Clinical epigenetics (2018)
Short-term and long-term exposures to high levels of CO, NO2, and PM2.5 were associated with alterations in differentially methylated regions of Foxp3. IL10 methylation showed a similar trend. For any given individual, these changes tend to be sustained over time. In addition, asthma was associated with higher differentially methylated regions of Foxp3 and IL10.