Association Between Psychiatric Polygenic Scores, Healthcare Utilization and Comorbidity Burden.

H Lester KirchnerDaniel RochaRichard K LinnerDrew WilimitisColin G WalshMichael RippergerHyunjoon LeeZhaowen LiuLea DavisYirui HuChristopher F ChabrisJordan W Smoller

Published in: medRxiv : the preprint server for health sciences (2023)

Polygenic score for depression is modestly associated with increased healthcare resource utilization and comorbidity burden, in the absence of diagnosis. Following a diagnosis of depression, the PGS was associated with further increases in healthcare utilization. These findings suggest that depression genetic risk is associated with utilization and burden of chronic disease in real-world settings.

Keyphrases

healthcare
depressive symptoms
sleep quality
health information
social media