Endothelial colony forming cell administration promotes neurovascular unit development in growth restricted and appropriately grown fetal lambs.

Alexander BellAshalyn P WattIngrid DudinkYen PhamAmy E SutherlandBeth J AllisonCourtney A McDonaldMargie Castillo-MelendezGraham JenkinAtul MalhotraSuzanne L MillerTamara Yawno

Published in: Stem cell research & therapy (2023)

ECFC administration enhanced development of NVU components in both the AGA and FGR fetal brain. Further investigation is required to assess how to optimise the enhanced angiogenic capabilities of ECFCs to provide a therapeutic strategy to protect the developing NVU against vulnerabilities associated with FGR.

Keyphrases

single cell
endothelial cells
cell therapy
white matter
stem cells
resting state
multiple sclerosis
brain injury
cerebral ischemia
subarachnoid hemorrhage