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A nano-integrated microfluidic biochip for enzyme-based point-of-care detection of creatinine.

Jianyong LiZhenhua LiYanzhi DouJing SuJiye ShiYi ZhouLihua WangShiping SongChun-Hai Fan
Published in: Chemical communications (Cambridge, England) (2021)
A nano-integrated portable enzymatic microfluidic electrochemical biochip was developed for single-step point-of-care testing of creatinine. The biochip could automatically eliminate a lot of interferences from practical biological samples and enzymatic intermediate products. Gold nanostructure- and carbon nanotube-based screen-printed carbon electrodes were integrated into microfluidic structures to improve the detection performance for creatinine. The microfluidic electrochemical biochip holds promise to become a practical device for medical diagnosis, especially POCT.
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