Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function.
Huaishan WangHui ChenShujing LiuJie ZhangHezhe LuRajasekharan SomasundaramRobin ChoiGao ZhangLingling OuJohn SchollerShifu TianLiyun DongGuo YeyeLili HuangThomas ConnellyLing LiAlexander HuangTara C MitchellYi FanCarl H JuneGordon B MillsWei GuoMeenhard HerlynGeorge X XuPublished in: Journal for immunotherapy of cancer (2022)
Vδ2 T cells expanded by IPP and resiquimod demonstrate improved anti-tumor function and have the potential to increase the efficacy of γδ T cell-based therapies.