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Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function.

Huaishan WangHui ChenShujing LiuJie ZhangHezhe LuRajasekharan SomasundaramRobin ChoiGao ZhangLingling OuJohn SchollerShifu TianLiyun DongGuo YeyeLili HuangThomas ConnellyLing LiAlexander HuangTara C MitchellYi FanCarl H JuneGordon B MillsWei GuoMeenhard HerlynGeorge X Xu
Published in: Journal for immunotherapy of cancer (2022)
Vδ2 T cells expanded by IPP and resiquimod demonstrate improved anti-tumor function and have the potential to increase the efficacy of γδ T cell-based therapies.
Keyphrases
  • toll like receptor
  • inflammatory response
  • immune response
  • cell proliferation
  • regulatory t cells
  • signaling pathway
  • risk assessment
  • human health
  • climate change