Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function.

Huaishan WangHui ChenShujing LiuJie ZhangHezhe LuRajasekharan SomasundaramRobin ChoiGao ZhangLingling OuJohn SchollerShifu TianLiyun DongGuo YeyeLili HuangThomas ConnellyLing LiAlexander HuangTara C MitchellYi FanCarl H JuneGordon B MillsWei GuoMeenhard HerlynGeorge X Xu

Published in: Journal for immunotherapy of cancer (2022)

Vδ2 T cells expanded by IPP and resiquimod demonstrate improved anti-tumor function and have the potential to increase the efficacy of γδ T cell-based therapies.

Keyphrases

toll like receptor
inflammatory response
immune response
cell proliferation
regulatory t cells
signaling pathway
risk assessment
human health
climate change