Definition of cortical bone involvement in the staging of newly diagnosed pediatric Hodgkin lymphoma: A report from the International Working Group on Staging Evaluation and Response Criteria Harmonization (SEARCH).
Jocelyn LewisKathleen McCartenLars KurchJamie E FlerlageSue C KasteRegine KlugeDietrich StoevesandtStephan D VossKara M KellyChristine Mauz-KörholzRichard A DrachtmanMonika L MetzgerPublished in: Pediatric blood & cancer (2019)
The SEARCH group for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL) proposes the following criteria as defining cortical bone involvement: any cortical bone biopsy-proven lesion; a positive bony window lesion on computer tomography (CT), with an FDG-PET positive correlate in a patient with biopsy-proven Hodgkin lymphoma, if there is no other typical skeletal pathology; auspicious skeletal lesions on FDG-PET or magnetic resonance imaging should be confirmed by CT or Tc-99m scan to distinguish cortical lesions from bone marrow involvement. Nodal masses that extend into bone with bony destruction are considered extranodal extension or "E" lesions and do not represent metastatic or stage IV disease.
Keyphrases
- hodgkin lymphoma
- pet ct
- computed tomography
- positron emission tomography
- bone mineral density
- magnetic resonance imaging
- young adults
- contrast enhanced
- bone marrow
- pet imaging
- lymph node
- newly diagnosed
- bone loss
- soft tissue
- bone regeneration
- dual energy
- image quality
- ultrasound guided
- squamous cell carcinoma
- small cell lung cancer
- childhood cancer
- postmenopausal women
- mesenchymal stem cells
- case report
- machine learning
- deep learning
- radiation therapy