Free-water DTI estimates from single b-value data might seem plausible but must be interpreted with care.
Marc GolubRafael Neto HenriquesRita Gouveia NunesPublished in: Magnetic resonance in medicine (2020)
The RGD FWE-DTI method has limited specificity; thus, its results from single-shell data should be carefully interpreted. When possible, multishell acquisitions and the nonlinear least-squares approach should be preferred instead.