Genetic analysis of ocular tumour-associated genes using large genomic datasets: insights into selection constraints and variant representation in the population.

Alexander Tanner Mandeep S Sagoo Omar A MahrooJose S Pulido

Published in: BMJ open ophthalmology (2024)

Our findings highlight the importance of negative selection in ocular tumour genes, supporting cranial gene conservation. This study provides insights into ocular tumourigenesis and future research avenues.

Keyphrases

genome wide
genome wide identification
copy number
optic nerve
genome wide analysis
dna methylation
bioinformatics analysis
transcription factor
current status
rna seq
optical coherence tomography
single cell