Enrichment of cell cycle pathways in progesterone-treated endometrial organoids of infertile women compared to fertile women.

Bich Ngoc Bui Arif Ibrahim ArdisasmitaF H van de VliertM S AbendrothM van HoeselS Mackens Sabine A Fuchs E E S Nieuwenhuis Frank J M Broekmans Gaby S Steba

Published in: Journal of assisted reproduction and genetics (2024)

This study revealed that cell cycle processes were enriched in E2/P4-treated infertile endometrial organoids as compared to fertile organoids. This could reflect persistently higher proliferative activity of the endometrial epithelial cells in differentiated infertile organoids compared to fertile organoids. To confirm this hypothesis, further studies are warranted.

Keyphrases

cell cycle
polycystic ovary syndrome
cell proliferation
induced pluripotent stem cells
insulin resistance
endometrial cancer
metabolic syndrome
pregnant women
single cell
cervical cancer screening
estrogen receptor