Evidence From Men for Ovary-independent Effects of Genetic Risk Factors for Polycystic Ovary Syndrome.

Jia ZhuNatàlia Pujol-GualdoLaura B L WittemansCecilia M LindgrenTriin LaiskJoel N HirschhornYee-Ming Chan

Published in: The Journal of clinical endocrinology and metabolism (2022)

Genetic risk factors for PCOS have phenotypic consequences in men, indicating that they can act independently of ovarian function. Thus, PCOS in women may not always be a primary disorder of the ovaries.

Keyphrases

polycystic ovary syndrome
insulin resistance
genome wide
middle aged
copy number
gene expression
pregnant women