Comparing proton pump inhibitors with histamin-2 receptor blockers regarding the risk of osteoporotic fractures: a nested case-control study of more than 350,000 Korean patients with GERD and peptic ulcer disease.
Joo-Hyun ParkJessie LeeSu-Yeon YuJin-Hyung JungKyungdo HanDo Hoon KimJinnie RheePublished in: BMC geriatrics (2020)
The risk of osteoporotic fracture increased with the duration of PPI use, especially when PPI was used for ≥1 year and regularly in the recent 1 year.