Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen.
Roux-Cil FerreiraSteven J ReynoldsAdam A CapoferriOwen BakerErin E BrownEthan KlockJernelle MillerJun LaiSharada SarafCharles KirbyBriana LynchJada HackmanSarah N GowanlockStephen TomusangeSamiri JamiruAggrey AnokTaddeo KityamuweesiPaul BuuleDaniel BrunoCraig MartensRebecca RoseSusanna L LamersRonald M GaliwangoArt F Y PoonThomas C QuinnJessica L ProdgerAndrew D ReddPublished in: medRxiv : the preprint server for health sciences (2023)
s DNA. We found that for approximately a year after this switch to the new drug, there was a temporary spike in the size of the latent viral reservoir despite the new drug continuing to completely suppress viral replication with no apparent adverse clinical effects.
Keyphrases
- hiv infected
- antiretroviral therapy
- sars cov
- adverse drug
- human immunodeficiency virus
- heart rate
- hiv positive
- circulating tumor
- hiv infected patients
- cell free
- single molecule
- heart rate variability
- drug induced
- diffusion weighted imaging
- emergency department
- electronic health record
- blood pressure
- computed tomography