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Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen.

Roux-Cil FerreiraSteven J ReynoldsAdam A CapoferriOwen BakerErin E BrownEthan KlockJernelle MillerJun LaiSharada SarafCharles KirbyBriana LynchJada HackmanSarah N GowanlockStephen TomusangeSamiri JamiruAggrey AnokTaddeo KityamuweesiPaul BuuleDaniel BrunoCraig MartensRebecca RoseSusanna L LamersRonald M GaliwangoArt F Y PoonThomas C QuinnJessica L ProdgerAndrew D Redd
Published in: medRxiv : the preprint server for health sciences (2023)
s DNA. We found that for approximately a year after this switch to the new drug, there was a temporary spike in the size of the latent viral reservoir despite the new drug continuing to completely suppress viral replication with no apparent adverse clinical effects.
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