Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells.

Raffaele Nuzzi Lola Buono Simona Scalabrin Marco De Iuliis Benedetta Bussolati

Published in: Stem cells international (2021)

Results highlight the already well-known proregenerative potential of MSC-EVs in a totally new biological model, the endothelium of the cornea. MSC-EVs, indeed, induced proliferation and survival of HCECs, promoting the migration of HCECs in vitro.

Keyphrases

endothelial cells
high glucose
stem cells
vascular endothelial growth factor
nitric oxide
signaling pathway
diabetic rats
induced pluripotent stem cells
wound healing
oxidative stress
mesenchymal stem cells