Headache during SARS-CoV-2 infection as an early symptom associated with a more benign course of disease: a case-control study.
Alicia Gonzalez-MartinezVíctor FanjulCarmen RamosJorge Serrano BallesterosMarta BustamanteAlmudena Villa MartíClaudia ÁlvarezYaiza García Del ÁlamoJosé VivancosAna Beatriz Gago-VeigaPublished in: European journal of neurology (2021)
Our results show that headache is associated with a more benign SARS-CoV-2 infection. COVID-19-associated headache appears as an early symptom and as a novel headache with characteristics of headache attributed to systemic viral infection. Further research addressing the underlying mechanisms to confirm these findings is warranted.