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Identification of Disease-relevant, Sex-based Proteomic Differences in iPSC-derived Vascular Smooth Muscle.

Nethika R AriyasingheDivya GuptaSean EscopeteAleksandr B StotlandNiveda SundararamanBen NguKruttika DabkeDeepika RaiLiam McCarthyRoberta S SantosMegan L McCainDhruv SareenSarah J Parker
Published in: bioRxiv : the preprint server for biology (2024)
In this work, we have differentiated 4 male and 4 female iPSC lines into vascular smooth muscle cells, giving us the ability to identify statistically-significant sex-specific proteomic markers that are relevant to cardiovascular disease risk (such as PCK2, MTOR, IGFBP2, PTGR2, and SULTE1).
Keyphrases
  • smooth muscle
  • vascular smooth muscle cells
  • cardiovascular disease
  • angiotensin ii
  • label free
  • induced pluripotent stem cells
  • type diabetes
  • cell proliferation
  • cardiovascular risk factors
  • bioinformatics analysis