Identification of Disease-relevant, Sex-based Proteomic Differences in iPSC-derived Vascular Smooth Muscle.
Nethika R AriyasingheDivya GuptaSean EscopeteAleksandr B StotlandNiveda SundararamanBen NguKruttika DabkeDeepika RaiLiam McCarthyRoberta S SantosMegan L McCainDhruv SareenSarah J ParkerPublished in: bioRxiv : the preprint server for biology (2024)
In this work, we have differentiated 4 male and 4 female iPSC lines into vascular smooth muscle cells, giving us the ability to identify statistically-significant sex-specific proteomic markers that are relevant to cardiovascular disease risk (such as PCK2, MTOR, IGFBP2, PTGR2, and SULTE1).