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Is there a role for the adverse outcome pathway framework to support radiation protection?

Vinita ChauhanZakaria SaidJoseph DakaBaki SadiDeepti BijlaniFrancesco MarchettiDanielle BeatonAdelene GawChunsheng LiJulie BurttJulie LeblancMarc DesrosiersMarilyne StuartMathieu BrossardNgoc Q VuongRuth WilkinsSami QutobJames McNameeYi WangCarole Yauk
Published in: International journal of radiation biology (2018)
Overall, participants agreed that by building AOPs in the radiation field, a network of data-sharing initiatives will enhance our interpretation of existing knowledge where current scientific evidence is minimal. They would provide new avenues to understand effects at low-dose and dose-rates and help to quantify the combined effect of multiple stressors on shared mechanistic pathways.
Keyphrases
  • low dose
  • healthcare
  • high dose
  • electronic health record
  • radiation induced
  • quality improvement
  • social media
  • big data
  • emergency department
  • machine learning
  • artificial intelligence