Is there a role for the adverse outcome pathway framework to support radiation protection?
Vinita ChauhanZakaria SaidJoseph DakaBaki SadiDeepti BijlaniFrancesco MarchettiDanielle BeatonAdelene GawChunsheng LiJulie BurttJulie LeblancMarc DesrosiersMarilyne StuartMathieu BrossardNgoc Q VuongRuth WilkinsSami QutobJames McNameeYi WangCarole YaukPublished in: International journal of radiation biology (2018)
Overall, participants agreed that by building AOPs in the radiation field, a network of data-sharing initiatives will enhance our interpretation of existing knowledge where current scientific evidence is minimal. They would provide new avenues to understand effects at low-dose and dose-rates and help to quantify the combined effect of multiple stressors on shared mechanistic pathways.