Early in life stressful events induce chronic visceral pain and changes in bladder function in adult female mice through a mechanism involving TRPV1 and alpha 1A adrenoceptors.
Rita MatosLiliana Santos-LeiteFrancisco CruzAna CharruaPublished in: Neurourology and urodynamics (2024)
MDM induced in female mice is able to mimic IC/BPS phenotype, through mechanisms involving A1AAR and TRPV1. Therefore, the modulation of both receptors may represent a therapeutic approach to treat IC/BPS patients.
Keyphrases
- end stage renal disease
- neuropathic pain
- high fat diet induced
- chronic kidney disease
- newly diagnosed
- ejection fraction
- chronic pain
- spinal cord injury
- prognostic factors
- insulin resistance
- high glucose
- drug induced
- type diabetes
- patient reported outcomes
- oxidative stress
- young adults
- wild type
- adipose tissue
- endothelial cells
- childhood cancer