Characterization of immunosuppressive myeloid cells in Merkel cell carcinoma: correlation with resistance to PD-1 pathway blockade.

Paul T Nghiem Shira Tabachnick-Cherny Thomas Pulliam Haroldo J Rodriguez Xinyi Fan Daniel S Hippe Daniel C Jones Ata S Moshiri Kimberly S Smythe Rima M Kulikauskas Lisa C Zaba Kelly G Paulson

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

This study further characterizes TAMs in MCC tumors and provides insights into their possible immunosuppressive mechanism. TAMs may reduce the likelihood of treatment response in MCC by counteracting the benefit of CD8 T-cell infiltration.

Keyphrases

induced apoptosis
cell cycle arrest
bone marrow
dendritic cells
acute myeloid leukemia
cell death
signaling pathway