CSF biomarkers of neurotoxicity in childhood cancer survivors after cranial radiotherapy or surgery.
Erik FernströmMarianne JarfeltMalin BlomstrandBirgitta LanneringMarkus AxelssonPontus WaslingThomas Björk-ErikssonHenrik ZetterbergMarie KalmPublished in: Annals of clinical and translational neurology (2024)
The results suggest a potential chronic low-grade neurodegeneration and astrocyte activation in patients treated for pediatric brain or skull base tumors. Protein biomarkers of CNS disease could potentially be used to increase our understanding of the contribution from different tumor treatments with regard to long-term symptoms in cancer patients.
Keyphrases
- low grade
- high grade
- childhood cancer
- minimally invasive
- early stage
- young adults
- coronary artery bypass
- resting state
- blood brain barrier
- locally advanced
- radiation induced
- functional connectivity
- multiple sclerosis
- amino acid
- early life
- sleep quality
- coronary artery disease
- human health
- surgical site infection
- small molecule
- climate change
- rectal cancer
- acute coronary syndrome