Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis.
Nila Hendrika ServaasSanne HiddinghEleni ChouriCatharina G K WichersAlsya J AffandiAndrea OttriaCornelis P J BekkerMarta CossuSandra C Silva-CardosoMaarten van der KroefAnneline C HinrichsTiago CarvalheiroNadia VazirpanahLorenzo BerettaMarzia RossatoFemke Bonte-MineurTimothy R D J RadstakeJonas J W KuiperMarianne BoesAridaman PanditPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
NR4A1, NR4A2, and NR4A3 are important regulators of immunosuppressive and fibrosis-associated pathways in SSc cDCs. Thus, the NR4A family represents novel potential targets to restore cDC homeostasis in SSc.