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Lumacaftor/ivacaftor initiation in two liver transplantation patients under tacrolimus and antifungal azoles.

Ikrame ChouchaneNathalie Stremler-LebelPhilippe Reix
Published in: Clinical case reports (2019)
We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation. Despite multiple drug-drug interactions, maintaining therapeutic TCS levels was achievable. During the following year, LUM/IVA was well tolerated, providing clinical benefits.
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