TREK-1 and TREK-2 knockout mice are not resistant to halothane or isoflurane.
Kira A SpencerChristian B WoodsHailey M WorstmanSimon C JohnsonJan-Marino RamirezPhilip G MorganMargaret M SedenskyPublished in: Anesthesiology (2023)
Loss of TREK channels did not alter anesthetic sensitivity in mice, nor did it eliminate isoflurane-induced transmembrane currents. However, the isoflurane-induced currents are norfluoxetine-resistant in Trek mutants indicating that other channels may function in this role when TREK channels are deleted.