Targeting CDK7 suppresses super enhancer-linked inflammatory genes and alleviates CAR T cell-induced cytokine release syndrome.

Ye WeiChong LiHuifang BianWei QianKairui JinTingting XuXiaomao GuoXueguan LuFengtao Su

Published in: Molecular cancer (2021)

Our work indicates the CDK7-dependent transcription addiction of inflammatory genes. Targeting CDK7 is a promising strategy for treating CRS by inhibiting multiple cytokines.

Keyphrases

cell cycle
signaling pathway
genome wide
oxidative stress
transcription factor
cancer therapy
genome wide identification
bioinformatics analysis
diabetic rats
single cell
high glucose
cell proliferation
cell therapy
case report
genome wide analysis
mouse model
gene expression
bone marrow
stress induced