MicroRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia.
Gaia SpinettiElena SangalliElena TagliabueDavide MaselliOrnella ColpaniDavid Ferland-McColloughFranco CarnelliPatrizia OrlandoAgostino PaccagnellaAnna FurlanPiero Maria StefaniLuisa SambadoMaria SambataroPaolo MadedduPublished in: Diabetes care (2020)
Migration of CD34+ cells predicts long-term cardiovascular mortality in T2D-CLI patients. An altered paracrine signaling conveys antiangiogenic and proapoptotic features from CD34+ cells to the endothelium. This damaging interaction may increase the risk for life-threatening complications.
Keyphrases
- induced apoptosis
- cell cycle arrest
- endothelial cells
- signaling pathway
- endoplasmic reticulum stress
- emergency department
- newly diagnosed
- oxidative stress
- coronary artery disease
- ejection fraction
- prognostic factors
- cardiovascular events
- patient reported outcomes
- pi k akt
- vascular endothelial growth factor
- drug induced
- human health