Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis.
Rosendo A RodriguezMatthew SpenceRichard HaeMohsen AgharaziiKevin D BurnsPublished in: Canadian journal of kidney health and disease (2020)
Pharmacologic interventions targeting aortic stiffness in ESRD have mixed effects on reducing cf-PWV, with some strategies suggesting potential benefit. The quality of evidence, however, is insufficient to draw definitive conclusions on their use to slow progression of aortic stiffness in ESRD. Further well-designed studies are needed to confirm these associations and their impact on cardiovascular outcomes in ESRD.Registered in PROSPERO (CRD42016033463).
Keyphrases
- end stage renal disease
- chronic kidney disease
- peritoneal dialysis
- aortic valve
- left ventricular
- pulmonary artery
- aortic dissection
- cystic fibrosis
- physical activity
- coronary artery
- squamous cell carcinoma
- heart failure
- case control
- radiation therapy
- drug delivery
- locally advanced
- atrial fibrillation
- risk assessment
- quality improvement
- climate change