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Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.

Jane GilmourLeigh O'ConnorChristopher P MiddletonPeter KeaneNynke GillemansJean-Baptiste CazierSjaak PhilipsenConstanze Bonifer
Published in: Epigenetics & chromatin (2019)
Our findings highlight the essential contribution of ubiquitous factors such as Sp1 to blood cell development. In contrast to tissue-specific transcription factors which are required to direct specific cell fates, loss of Sp1 leads to a widespread deregulation in timing and coordination of differentiation trajectories during hematopoietic specification.
Keyphrases
  • transcription factor
  • single cell
  • bone marrow
  • cell therapy
  • depressive symptoms
  • dna binding
  • magnetic resonance imaging
  • cell fate