Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.
Jane GilmourLeigh O'ConnorChristopher P MiddletonPeter KeaneNynke GillemansJean-Baptiste CazierSjaak PhilipsenConstanze BoniferPublished in: Epigenetics & chromatin (2019)
Our findings highlight the essential contribution of ubiquitous factors such as Sp1 to blood cell development. In contrast to tissue-specific transcription factors which are required to direct specific cell fates, loss of Sp1 leads to a widespread deregulation in timing and coordination of differentiation trajectories during hematopoietic specification.