A systematic review and meta-analysis: the diagnostic accuracy of methylated SEPTIN9 for the detection of hepatocellular carcinoma and the clinical evaluation of its use in combination with other surveillance modalities.

Subashini Chandrapalan Ayman S BannagaAlice WeidnerMegan P HitchinsRamesh Pulendran Arasaradnam

Published in: Scandinavian journal of gastroenterology (2021)

Test combinations have superior performance for the detection of HCC than any individual test. mSEPT9 has shown promise in the detection of HCC with higher estimates of performance accuracy. mSEPT9 has potential for use as an HCC surveillance modality in adjunct with other tests to improve detection rates. However, cost effectiveness of this approach needs further evaluation.

Keyphrases

loop mediated isothermal amplification
real time pcr
label free
machine learning
big data
climate change
artificial intelligence
sensitive detection